|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 246 of Human NCOA3|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29854 targets NCOA3 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29854 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 246 of Human NCOA3.
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACTR; AIB-1; AIB1; Amplified in breast cancer 1 protein; bHLHe42; CAGH16; CBP-interacting protein; Class E basic helix-loop-helix protein 42; CTG26; KAT13B; NCoA-3; Nuclear receptor coactivator 3; pCIP; RAC-3; RAC3; Receptor-associated coactivator 3; SRC-3; SRC3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC14; TNRC16; TRAM-1
Gene Aliases: ACTR; AIB-1; AIB1; BHLHE42; CAGH16; CTG26; KAT13B; NCOA3; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; TRAM1
UniProt ID: (Human) Q9Y6Q9
Entrez Gene ID: (Human) 8202
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