|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 239 and 516 of Human NCOA62|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29070 targets NCOA62 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-29070 immunogen is recombinant fragment corresponding to a region within amino acids 239 and 516 of Human NCOA62.
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 62-kD; Bx42; homolog of Drosophila BX42; NCOA-62; Nuclear protein SkiP; nuclear receptor coactivator; Nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; Prp45; PRPF45; SKI interacting protein; SKI-interacting protein; SKIIP; SKIP; SNW domain-containing protein 1
Gene Aliases: 2310008B08Rik; AW048543; Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP; SNW1
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