|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
|Immunohistochemistry (Paraffin) (IHC (P))||1:1000|
|Western Blot (WB)||1:5000|
|Tested Species reactivity||Bovine, Human, Mammal, Mouse, Pig, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Native NF-L purified from pig spinal cord|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-32240 detects NEFL from rat, human, mouse, porcine samples.
PA1-32240 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue), Western blot applications.
The PA1-32240 immunogen is: Native NF-L purified from pig spinal cord
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Protein Aliases: 68 kDa neurofilament protein; CMT1F; CMT2E; FLJ53642; light molecular weight neurofilament protein; Micro glutamic acid-rich protein; Neurofilament light polypeptide; neurofilament protein; neurofilament protein L; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet L protein; neurofilament, light polypeptide 68kDa; NF-L; NF68; NFL; protein phosphatase 1, regulatory subunit 110
Gene Aliases: AI847934; BOS_9100; CMT1F; CMT2E; NEFL; NF-L; NF68; NFL; PPP1R110; XNF-L