|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide N(263) K R K Y S L N G R Q P P Y S P H H S(282) of human NFaTc1|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Suggested positive control: antigen standard for NFATC1 (transient overexpression lysate).
NFAT (nuclear factor of activated T cell transcription factors play critical roles in gene transcription during immune responses. The NFAT complex is made up of NFATc (NFATc1-4) protein and activator protein-1 (AP-1) transcription factor. NFAT proteins are regulated by Ca2+. NFATc1 is a substrate protein phosphatase calcineurin, a critical mediator of calcium signals during T-cell activation. NFATc1 activation requires the translocation of the transcription factor into the nucleus, a process that is mediated by calcineurin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: calcineurin-dependent 1; cytoplasmic; MGC138448; NF-ATC; NF-ATc1; NFAT trans; NFAT transcription complex cytosolic component; NFAT2; NFATC; NFATC1; nuclear factor of activated T-cells; nuclear factor of activated T-cells 'c'; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor NF-ATc
Gene Aliases: 2210017P03Rik; AI449492; AV076380; NF-ATC; NF-ATc1.2; NFAT2; NFATC; NFATC1; Nfatcb
UniProt ID: (Human) B5B2M6
Molecular Function: transcription factor
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