|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide - KLH conjugated. Sequence identity/similarity to Mouse: 53/58%.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-24586 detects NIMA-Related Kinase 9 in Human samples.
PA1-24586 has been successfully used in Immunohistochemistry (paraffin) procedures.
PA1-24586 immunogen corresponds to Synthetic peptide - KLH conjugated. Sequence identity/similarity to Mouse: 53/58%.
NEK9, a NEK type protein kinase, regulates chromosome alignment and segregation in mitosis. The protein has a N-terminal NIMA-like catalytic domain, a central domain with homology to the guanine nucleotide exchange factor for the GTPase Ran (RCC1), and a C-terminal coiled-coil domain. It is phosphorylated by active p34(Cdc2) and is capable of autophosphorylation and oligomerization. The activated protein binds Nek6 and RCC1, and has been shown to associate with the human homolog of the Drosophila protein Bicaudal D (Bicd2) in vivo and to phosphorylate this coiled-coil protein in vitro. NEK9 expression has been documented in normal human brain. ESTs have been isolated from several tissue libraries, including normal bone, lymph and thymus and cancerous cervix, eye, lymph and placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Never in mitosis A-related kinase 7; Never In Mitosis Gene A-Related Kinase 9; NIMA (never in mitosis gene a)-related kinase 7; NIMA-related kinase 7; NimA-related protein kinase 7; Serine/threonine-protein kinase Nek7
Gene Aliases: NEK7
UniProt ID: (Human) Q8TDX7
Entrez Gene ID: (Human) 140609
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