|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 27 and 261 of Human NIPA|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29367 targets NIPA in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-29367 immunogen is recombinant fragment corresponding to a region within amino acids 27 and 261 of Human NIPA.
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1110054L24Rik; hematopoietic stem/progenitor cell protein 216; hNIPA; mNIPA; NIPA; nuclear interacting partner of ALK; nuclear interacting partner of anaplastic lymphoma kinase (ALK); nuclear interaction partner of ALK; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; zinc finge; Zinc finger C3HC-type protein 1; zinc finger, C3HC-type containing 1
Gene Aliases: 1110054L24Rik; AU018540; AU019789; HSPC216; NIPA; ZC3HC1
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