|Immunoprecipitation (IP)||3 µg/200µg lysate|
|Western Blot (WB)||1:1000|
|Immunocytochemistry (ICC)||See 1 publications below|
|Western Blot (WB)||See 2 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat Mouse|
|Host / Isotype||Mouse|
|Immunogen||Fusion protein containing amino acids 1-564 of the NR1 subunit of rat GRIN1|
|Storage buffer||tissue culture supernatant, pH 7.4|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
In Western blot, this antibody detects a single ~120 kDa protein representing NR1 in rat brain homogenate. It shows no cross-reactivity with any of the NR2 subunits.
Reconstitute with 50 ul of PBS.
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GluN1; glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-Methyl-D-Aspartate Receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; pGluN1
Gene Aliases: GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; M100174; MRD8; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174
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