|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 193 of Human NOB1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-31785 targets NOB1 in WB applications and shows reactivity with Human samples.
The PA5-31785 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 193 of Human NOB1.
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adenocarcinoma antigen recognized by T lymphocytes 4; ART-4; MST158; nin one binding protein; NIN1/RPN12 binding protein 1 homolog; NOB1P; Phosphorylation regulatory protein HP-10; Protein ART-4; PSMD8 binding protein 1; PSMD8BP1; RNA-binding protein NOB1
Gene Aliases: ART-4; ART4; MST158; MSTP158; NOB1; NOB1P; PSMD8BP1
UniProt ID: (Human) Q9ULX3
Entrez Gene ID: (Human) 28987
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