|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 187 and 431 of Human NP2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30105 targets NP2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30105 immunogen is recombinant fragment corresponding to a region within amino acids 187 and 431 of Human NP2.
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: apexin; NARP; neuronal activity-regulated pentaxin; Neuronal pentraxin II; Neuronal pentraxin-2; NP-II; NP2
Gene Aliases: NARP; NP-II; NP2; NPTX2
UniProt ID: (Human) P47972
Entrez Gene ID: (Human) 4885
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