|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:250|
|Western Blot (WB)||1:500|
|Tested Species reactivity||Human, Mouse, Pig, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to an internal region of rat NPC1L1(between residues 1000-1100).|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
The target sequence has 93% sequence homology with human.
Dietary consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, which factor into the risk of coronary heart disease. Niemann-Pick type C1 Like 1 protein (NPC1L1 or NPC3) is enriched in the small intestine and is found in the brush border membrane of enterocytes. It plays a critical role in absorption of intestinal cholesterol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BC 400-127; Niemann-Pick C1-like protein 1; Niemann-Pick C3; Niemann-Pick disease, type C1; Niemann-Pick disease, type C1-like 1; Niemann-Pick type C1 Like 1 Protein; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1 like 1; NPC1-like 1; NPC1L1; NPC3
Gene Aliases: 9130221N23Rik; Gm243; NPC11L1; NPC1L1
Molecular Function: receptor
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