|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 143 and 541 of Human NR5A2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28347 targets NR5A2 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-28347 immunogen is recombinant fragment corresponding to a region within amino acids 143 and 541 of Human NR5A2.
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; B1F; B1F2; CPF; CYP7A promoter-binding factor; fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTZ-F1; FTZ-F1beta; hB1F; hB1F-2; hepatocyte transcription factor which activates enhancer II of hepatitis B virus; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; liver nuclear receptor homolog-1 variant 2; Liver receptor homolog 1; LRH-1; LRH1; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2
Gene Aliases: AU020803; B1F; B1F2; CPF; D1Ertd308e; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; NR5A2; UF2-H3B
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