|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||Assay-Dependent|
|Tested Species reactivity||Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1017 and 1270 of NTE|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
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Protein Aliases: iPLA2delta; Neuropathy target esterase; NTEMND; patatin-like phospholipase domain containing 6; Patatin-like phospholipase domain-containing protein 6; PNPLA6; SPG39; Swiss cheese; Swiss-cheese
Gene Aliases: AI661849; MSws; Nte; Pnpla6
UniProt ID: (Mouse) Q3TRM4
Entrez Gene ID: (Mouse) 50767
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