|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||0.1-1 µg/ml|
|Western Blot (WB)||See 4 publications below|
|Immunofluorescence (IF)||See 1 publications below|
|Flow Cytometry (Flow)||See 1 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Hamster , Mouse , Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human Nectin-1 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region. This protein acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome as well as non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD111; ectodermal dysplasia 4 (Margarita Island type); herpes simplex virus type 1 sensitivity; Herpes virus entry mediator C; Herpesvirus entry mediator C; Herpesvirus Ig-like receptor; HIgR; HVEC; nectin 1; Nectin cell adhesion molecule 1; Nectin-1; nectin-1 alpha; nectin-1 delta; poliovirus receptor-like 1; poliovirus receptor-related 1 (herpesvirus entry mediator C); Poliovirus receptor-related protein 1; PRR1; PVRL1
Gene Aliases: AI835281; AW549174; CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; NECTIN1; OFC7; PRR; PRR1; PVRL1; PVRR; PVRR1; SK-12
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