|Immunohistochemistry (IHC)||Assay Dependent|
|Tested Species reactivity||Zebrafish|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (EKSKHLQDQLK) corresponding to the internal amino acids of nf2|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene encodes a protein that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC123124; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2b (merlin); nf2; NF2a
Gene Aliases: nf2; NF2a
Entrez Gene ID: (Zebrafish) 405887
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