|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 53 and 280 of Nicotinic Acetylcholine Receptor alpha 4 (Uniprot ID#P43681)|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-34714 targets Nicotinic Acetylcholine Receptor alpha 4 in WB applications and shows reactivity with Human samples.
The PA5-34714 immunogen is recombinant fragment corresponding to a region within amino acids 53 and 280 of Nicotinic Acetylcholine Receptor alpha 4 (Uniprot ID#P43681).
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha polypeptide 4; BFNC; cholinergic receptor; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; CHRNA 4; CHRNA4; EBN; EBN1; NACHR; NACHRA4; NACRA4; Neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; nicotinic
Gene Aliases: BFNC; CHRNA4; EBN; EBN1; NACHR; NACHRA4; NACRA4
UniProt ID: (Human) P43681
Entrez Gene ID: (Human) 1137
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