|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 339 of NuMA|
|Storage buffer||PBS, pH 7|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA5-17286 targets NuMA in WB applications and shows reactivity with Human samples.
The MA5-17286 immunogen is recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 339 of NuMA.
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: centrophilin stabilizes mitotic spindle in mitotic cells; NMP-22; Nuclear matrix protein-22; Nuclear mitotic apparatus protein 1; NuMA protein; SP-H antigen; structural nuclear protein
Gene Aliases: NMP-22; NMP22; NUMA; NUMA1
UniProt ID: (Human) Q14980
Entrez Gene ID: (Human) 4926
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