|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 339 of NuMA|
|Storage buffer||PBS, pH 7|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA5-17293 targets NuMA in ICC, IF, and WB applications and shows reactivity with Human samples.
The MA5-17293 immunogen is recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 339 of NuMA.
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: centrophilin stabilizes mitotic spindle in mitotic cells; NMP-22; Nuclear matrix protein-22; Nuclear mitotic apparatus protein 1; NuMA protein; SP-H antigen; structural nuclear protein
Gene Aliases: NMP-22; NMP22; NUMA; NUMA1
UniProt ID: (Human) Q14980
Entrez Gene ID: (Human) 4926
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.