|Immunofluorescence (IF)||1:100 - 1:1000|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100 - 1:1000|
|Western Blot (WB)||1:100 - 1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Recombinant protein corresponding to 150 N-terminal residues of human Nup358.|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-847 detects Nup358/RanBP2 from human samples.
Nup358 is an essential protein needed for proper kinetochore function. Chromatin congregation and segregation are distributed in the absence of Nup358. The assembly of other kinetochore components is also strongly inhibited. Therefore, Nup358 plays an essential role in the association of kinetochore function and maturation and nuclear envelope breakdown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 358 kDa nucleoporin; acute necrotizing encephalopathy 1 (autosomal dominant); ANE1; E3 SUMO-protein ligase RanBP2; Nuclear pore complex protein Nup358; nucleoporin 358; Nucleoporin Nup358; NUP358; P270; Ran-binding protein 2; RanBP2; transformation-related protein 2; TRP1; TRP2
Gene Aliases: ADANE; ANE1; IIAE3; NUP358; RANBP2; TRP1; TRP2
UniProt ID: (Human) P49792
Entrez Gene ID: (Human) 5903
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