|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 300-350 of human Oct-6|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 45 kDa.
Purity is >95% by SDS-PAGE.
POU homeodomain proteins are transcriptional regulators that function in various developmental processes (e.g. cell division, differentiation, specification and survival of specific cell types) and participate in the determination of cell fate. The 45 kDa POU transcription factor Oct-6 (also designated SCIP and Tst-1) is expressed by late embryonic Schwann cells of the peripheral nervous system and is also expressed by nonmyelinating Schwann cells in adults. Oct-6 is strongly upregulated in promyelin cells because it is required for the timely differentiation of promyelin cells into myelinating cells. Oct-6 functions during myelination and is required for the proper downregulation of its own gene when myelination proceeds. c-Myc can act synergistically with the POU domain of Oct-6 to produce myelin disease pathogenesis in the mammalian central nervous system.
Protein Aliases: class 3; Oct-6; OCT6; octamer binding factor oct6; Octamer-binding protein 6; Octamer-binding transcription factor 6; octoamer transcription factor-6; octomer-6; OTF-6; OTF6; POU domain; POU domain transcription factor SCIP; POU domain, class 3, transcription factor 1; POU3F1; suppressed cAMP-inducible POU; transcription factor 1; Tst-1
Gene Aliases: Oct-6; OCT6; Otf-6; OTF6; POU3F1; SCIP; Test1; Testes-1; Tst-1; Tst1