|Immunohistochemistry (Paraffin) (IHC (P))||4 µg/ml|
|Tested Species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 19 amino acid peptide from 2nd extracellular domain of human Kappa Opioid Receptor.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Horse, Rabbit (100%).
Activation of the kappa-opioid receptor oppposes a variety of µ-opioid receptor mediated actions throughout the brain and spinal cord. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channels activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: K-OR-1; kappa 1; Kappa opioid receptor; kappa-1; Kappa-type opioid receptor; KOR; KOR-1; Opiate receptor; Opiate receptor, kappa-1; Opioid receptor; Opioid receptor kappa; opioid receptor, kappa 1; OPRK; OPRK1; Ork1
Gene Aliases: K-OR-1; KOR; KOR-1; OPRK; OPRK1; Ror-d
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