|ELISA (ELISA)||5-10 µg/mL|
|Tested Species reactivity||Chemical|
|Host / Isotype||Sheep / IgG|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-75328 specifically detects Oxazepam.
PA1-75328 has been successfully used in ELISA applications.
The PA1-75328 immunogen is Oxazepam(N)-BSA.
Oxazepam is only found in individuals that have used or taken this drug. It is an intermediate-acting benzodiazepine used to treat alcohol withdrawal and anxiety disorders. Similar to other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA-A receptors through a cooperative mechanism of action. GABA receptors are ionotropic chloride-linked channel receptors that produce inhibitory postsynaptic potentials. When activated by GABA, the GABA receptor/chloride ionophore complex undergoes a conformational change that allows the passage of chloride ions through the channel. Benzodiazepines are believed to exert their effect by increasing the effect of GABA at its receptor. Benzodiazepine binding increases chloride conductance in the presence of GABA by increasing the frequency at which the channel opens. In contrast, barbiturates increase chloride conductance in the presence of GABA by prolonging the time in which the channel remains open. There are 18 subtypes of the GABA receptor subunits. The a2 subunit of the alpha-2, beta-3, gamma-2 receptor complex is thought to mediate anxiolytic effects while the a1 subunit of the alpha-1, beta-2, gamma-2 receptor complex is thought to mediate sedative, anticonvulsant and anterograde amnesia effects. [National Center for Biotechnology Information. PubChem Compound Database; CID=4616]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adumbran; C15H11ClN2O2; Droxacepam; Durazepam; Serax; Tazepam
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