|ELISA (ELISA)||5-10 µg/mL|
|Tested Species reactivity||Chemical|
|Host / Isotype||Sheep / IgG|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-75335 specifically detects Oxycodone.
PA1-75335 has been successfully used in ELISA applications.
The PA1-75335 immunogen is Oxycodone(N)-BSA.
Oxycodone is a semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=5284603]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C18H21NO4; Dihydrohydroxycodeinone; Dihydrone; Dihydroxycodeinone; Oxycodeinone; Oxycontin
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