|Flow Cytometry (Flow)||1:50-1:200|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA.|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
This antibody does not react with mouse or rat.
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is human kidney. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABC20; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; Multidrug resistance protein 1; P-glycoprotein 1; P-GP; PGY1
Gene Aliases: ABC20; ABCB1; CD243; CLCS; GP170; MDR1; P-GP; PGY1
UniProt ID: (Human) P08183
Entrez Gene ID: (Human) 5243
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