|Western Blot (WB)||0.3-1 ug/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (ATNVSAHGSQANSPS) corresponding to the internal amino acids of PBX1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine based on sequence homology.
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, tinvolving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein Aliases: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; PBX1; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1
Gene Aliases: 2310056B04Rik; D230003C07Rik; Pbx-1; PBX1; PRL