|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 93 and 390 of Human PC1/3|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29832 targets PC1/3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29832 immunogen is recombinant fragment corresponding to a region within amino acids 93 and 390 of Human PC1/3.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMIQ12; NEC 1; NEC1; Neuroendocrine convertase 1; PC1; Prohormone convertase 1; prohormone convertase 3; Proprotein convertase 1; SPC3
Gene Aliases: BMIQ12; NEC1; PC1; PC3; PCSK1; SPC3
UniProt ID: (Human) P29120
Entrez Gene ID: (Human) 5122
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