|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 17 amino acid peptide from internal region of human PDE11A.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5'-cyclic-AMP and -GMP phosphodiesterase 11A; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; dual 3'; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; PPNAD2
Gene Aliases: PDE11A; PPNAD2
UniProt ID: (Human) Q9HCR9
Entrez Gene ID: (Human) 50940
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