|Flow Cytometry (Flow)||1:200 - 1:400|
|Immunohistochemistry (IHC)||1:200 - 1:1000|
|Western Blot (WB)||1:500 - 1:2000|
|Tested Species reactivity||Human, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human PDE1B (amino acids: 370-536) expressed in E. Coli.|
|Storage buffer||PBS with 0.5% proprietary stabilizer|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA5-17147 targets PDE1B in FACS, IHC, pep-ELISA, and WB applications and shows reactivity with Human and Rat samples.
The MA5-17147 immunogen is purified recombinant fragment of human PDE1B (amino acids: 370-536) expressed in E. Coli.
MA5-17147 detects PDE1B which has a predicted molecular weight of approximately 61.4kDa.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 63 kDa Cam-PDE; anti-oxidant protein 2; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-stimulated phosphodiesterase PDE1B1; Cam-PDE 1B; cyclic nucleotide phosphodiesterase (CaM-PDE); epididymis secretory sperm binding protein Li 79p; phosphodiesterase 1B, Ca2+calmodulin dependent; phosphodiesterase 1B, calmodulin-dependent; phosphodiesterase 1B1 Ca2+-calmodulin dependent 63 kDa; phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa; phosphodiesterase IB calmodulin-dependent; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B
Gene Aliases: Aop2; HEL-S-79p; PDE1B; PDE1B1; PDES1B
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