|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 491 and 736 of Human PDE4B|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29833 targets PDE4B in WB applications and shows reactivity with Human samples.
The PA5-29833 immunogen is recombinant fragment corresponding to a region within amino acids 491 and 736 of Human PDE4B.
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5'-cyclic phosphodiesterase 4B; cAMP-specific (phosphodiesterase E4 dunce homolog; cAMP-specific 3'; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase-4 B isoform; DPDE4; Drosophila); dunce-like phosphodiesterase E4; PDE32; PDE4B5; PDEIVB; phosphodiesterase 4B; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
Gene Aliases: DPDE4; PDE4B; PDEIVB
UniProt ID: (Human) Q07343
Entrez Gene ID: (Human) 5142
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