|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to an internal region of the human PINK1 protein (within residues 350-500).|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson and quote;s disease are triggered. PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BRPK; mitochondrial; PARK6; protein kinase BRPK; PTEN-induced putative kinase protein 1; serine/threonine-protein kinase PINK1; Serine/threonine-protein kinase PINK1, mitochondrial
Gene Aliases: 1190006F07Rik; AU042772; AW557854; BRPK; mFLJ00387; PARK6; PINK1
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