|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 20 and 300 of Human PKC nu|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30729 targets PKC nu in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30729 immunogen is recombinant protein fragment corresponding to a region within amino acids 20 and 300 of Human PKC nu.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EPK2; nPKC-NU; nu; PKC-NU; PKD3; PRKCN; protein kinase C; Protein kinase C nu type; Protein kinase EPK2; protein-serine/threonine kinase; Serine/threonine-protein kinase D3
Gene Aliases: EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN; PRKD3
UniProt ID: (Human) O94806
Entrez Gene ID: (Human) 23683
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