|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
|Western Blot (WB)||Assay-Dependent|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Amino acids 199-216 DLGRKGLEGMIRKRSGGH of human PLD2 protein were used as the immunogen.|
|Storage buffer||whole serum with 50% glycerol|
|Contains||0.025% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PLD2 is a peripheral membrane protein belonging to phospholipase D family with a PH domain, two PLD phosphodiesterase domains and a PX (phox homology) domain that plays a regulatory rather than catalytic role. PLD2 catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid and choline. PLD2 may function in regulated secretion, signal-induced cytoskeletal regulation and/or endocytosis, transcriptional regulation, and cell cycle control. It is usually stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and activated by the ADP-ribosylation factor-1 (ARF-1). PLD2 is activated by agonist stimulation of both tyrosine kinase and G protein-coupled receptors and is also known to interact with EGFR and PIP5K1A. PLD2, localized to plasma membrane caveolae, is ubiquitously expressed in most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Choline phosphatase 2; hPLD2; Phosphatidylcholine-hydrolyzing phospholipase D2; Phospholipase D2; PLD 2; PLD1C
Gene Aliases: PLD2
UniProt ID: (Human) O14939
Entrez Gene ID: (Human) 5338
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