|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 921 and 1129 of Human PPP2R3A|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30127 targets PPP2R3A in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30127 immunogen is recombinant protein fragment corresponding to a region within amino acids 921 and 1129 of Human PPP2R3A.
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha isoform and (PR 130); beta isoform; PP2A subunit B isoform PR72/PR130; PP2A subunit B isoform R3 isoform; PP2A subunit B isoforms B''-PR72/PR130; PP2A subunit B isoforms B72/B130; PP2A, subunit B, R3 isoform; PPP2R3; PR130; PR72; protein phosphatase 2 (formerly 2A); protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform; protein phosphatase 2 regulatory subunit B'', alpha; protein phosphatase 2, regulatory subunit B'', alpha; R3 isoform; regulatory subunit B'' (PR 72); serine/threo; Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha; subunit B
Gene Aliases: PPP2R3; PPP2R3A; PR130; PR72
UniProt ID: (Human) Q06190
Entrez Gene ID: (Human) 5523
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