|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Bovine, Human, Mouse, Rat|
|Host / Isotype||Sheep / IgG|
|Purification||Ammonium sulfate precipitation|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PP-X; pp4; PP4C; protein phosphatase 4 (formerly X), catalytic subunit; protein phosphatase 4, catalytic subunit; Protein phosphatase X; protein phosphatase X, catalytic subunit; Serine/threonine-protein phosphatase 4 catalytic subunit
Gene Aliases: 1110002D08Rik; AU016079; BOS_22898; PP-X; PP4; PP4C; PPH3; PPP4; PPP4C; PPX
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