|ChIP assay (ChIP)||1:100|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant GST fusion protein encoding aa 1-347 of RIZ1.|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GATA-3 binding protein G3B; GATA-3-binding protein G3B; KMT8; Lysine N-methyltransferase 8; MTB-ZF; MTE-binding protein; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; PR-domain zinc finger protein 2 (PRDM2) Retinoblastoma protein-interacting zinc-finger protein (RIZ1) (MTE-binding protein) (MTB-ZF).; retinoblastoma protein-binding zinc finger protein; Retinoblastoma protein-interacting zinc finger protein; Zinc finger protein RIZ; zinc-finger DNA-binding protein
Gene Aliases: 4833427P12Rik; E330024L24Rik; Gm1033; Gm19732; HUMHOXY1; KMT8; MTB-ZF; PRDM2; RIZ; RIZ1; RIZ2; Znfpr1c1
UniProt ID: (Human) Q13029
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