|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 224 of Human PSCD1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27793 targets PSCD1 in WB applications and shows reactivity with Human samples.
The PA5-27793 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 224 of Human PSCD1.
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B2-1; cytoadhesin 1; CYTOHESIN-1; D17S811E; homolog of secretory protein SEC7; PH; PH, SEC7 and coiled-coil domain-containing protein 1; pleckstrin homology; pleckstrin homology, Sec7 and coiled-coil domains 1; PSCD1; SEC7; SEC7 and coiled-coil domain-containing protein 1; Sec7 and coiled-coil domains 1; SEC7 homolog B2-1
Gene Aliases: B2-1; CYTH1; CYTOHESIN-1; D17S811E; PSCD1; SEC7
UniProt ID: (Human) Q15438
Entrez Gene ID: (Human) 9267
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.