|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment contain a sequence corresponding to a region within amino acids 66 and 406 of PSMC5|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28234 targets PSMC5 in IF, IHC (P), and WB applications and shows reactivity with Human, mouse and rat samples.
The PA5-28234 immunogen is a recombinant fragment corresponding to a region within amino acids 66 and 406 of PSMC5.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; for proteasomal ATPase (SUG1); mSUG1; MSUG1 protein; p45/SUG; peptidase (prosome, macropain) 26S subunit, ATPase 5; protease (prosome, macropain) 26S subunit, ATPase 5; proteasomal ATPase (SUG1); proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome 26S ATPase subunit 5; Proteasome 26S subunit ATPase 5; proteasome p45/SUG; Proteasome subunit p45; SUG-1; SUG1; Tat-binding protein homolog 10; testicular tissue protein Li 149; thy; Thyroid hormone receptor-interacting protein 1; thyroid receptor interactor 1; TRIP1
Gene Aliases: mSUG1; p45; p45/SUG; PSMC5; S8; SUG-1; SUG1; TBP10; TRIP1
Molecular Function: hydrolase
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