|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 47 and 324 of Human PSMD7|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27941 targets PSMD7 in IF and WB applications and shows reactivity with Human samples.
The PA5-27941 immunogen is recombinant fragment corresponding to a region within amino acids 47 and 324 of Human PSMD7.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 7; 26S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; 7 (Mov34 homo; macropain) 26S subunit; Moloney leukemia virus-34 proviral integration; MOV34; Mov34 homolog; Mov34 protein homolog; non-ATPase; proteasome (prosome; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog); Proteasome subunit p40; Rpn8
Gene Aliases: MOV34; MOV34L; P40; PSMD7; Rpn8; S12
UniProt ID: (Human) P51665
Entrez Gene ID: (Human) 5713
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