|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Chicken, Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
PA1-4134 detects Patched (PTCH) in human samples.
PA1-4134 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~158 kDa protein representing PTCH in fetal brain lysate.
The PA1-4134 immunogen is a synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH. This sequence is 100% conserved in human, rat, and chicken PTCH, and is expected to cross react with these samples.
Mutations of the human Patched tumor suppressor gene (PTCH) have been identified in individuals with the nevoid basal cell carcinoma syndrome (NBCCS) as well as in sporadic basal cell carcinomas and medulloblastomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mesenchymal dysplasia; Patched; Patched 1; patched homolog 1; patched homolog 2; patched protein; patched-like protein; Protein patched homolog 1; PTC; PTC1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3,4,5; Ptch1 protein +12b
Gene Aliases: A230106A15Rik; BCNS; HPE7; mes; NBCCS; PTC; PTC1; PTCH; PTCH1; PTCH11; Ptch2
Molecular Function: receptor
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