|Immunohistochemistry (Paraffin) (IHC (P))||3 - 6 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide from cytoplasmic domain of human PTPRE.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
The protein encoded by this gene is a member of the protein tyrosine phosphatase family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HPTPE; protein tyrosine phosphatase, receptor type, E; protein tyrosine phosphatase, receptor type, epsilon polypeptide; Protein-tyrosine phosphatase epsilon; PTP epsilon; PTPE; Ptpepsilon; PTPRE; PTPvarepsilon; R-PTP-EPSILON; Receptor-type tyrosine-protein phosphatase epsilon
Gene Aliases: HPTPE; PTPE; PTPRE; R-PTP-EPSILON
UniProt ID: (Human) P23469
Entrez Gene ID: (Human) 5791
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.