|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 94-125 amino acids from the N-terminal region of human PTPRN2|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PTPIA2beta is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IAR; IAR/receptor-like protein-tyrosine phosphatase; Islet cell autoantigen-related protein; Phogrin; protein tyrosine phosphatase receptor pi; protein tyrosine phosphatase receptor-type N polypeptide 2; protein tyrosine phosphatase, receptor type, N polypeptide 2; protein tyrosine phosphatase, receptor-type, N polypeptide 2; PTP NE-6; PTPNE6; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2; tyrosine phosphatase IA-2 beta
Gene Aliases: IA-2beta; IAR; ICAAR; KIAA0387; PTPRN2; PTPRP; R-PTP-N2
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