|Western Blot (WB)||1-3 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (DQNRDLKQGDDDDSK) corresponding to the internal amino acids of PUM2|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine based on sequence homology.
PUM2 is a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. This protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of this protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation.
Protein Aliases: FLJ36528; KIAA0235; MGC138251; MGC138253; OTTHUMP00000200539; PUM2; PUMH2; pumilio (Drosphila) homolog 2; Pumilio homolog 2; pumilio homolog 2 (Drosophila); pumilio RNA-binding family member 2; Pumilio-2; PUML2
Gene Aliases: KIAA0235; PUM2; PUMH2; PUML2
UniProt ID: (Human) D6W527
Entrez Gene ID: (Human) 23369