|Immunohistochemistry (IHC)||2-4 ug/ml|
|Western Blot (WB)||1-3 ug/ml|
|Immunohistochemistry (IHC)||See 2 publications below|
|Western Blot (WB)||See 1 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Immunohistochemistry (Frozen) (IHC (F))||See 1 publications below|
|Tested Species reactivity||Mouse|
|Published species reactivity||Rat , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), which is identical to rat and 92% homologous to human sequence.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MRS1; Pannexin 1; Pannexin-1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
Gene Aliases: AI847747; Panx1
UniProt ID: (Mouse) Q9JIP4
Entrez Gene ID: (Mouse) 55991
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