|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 454-483 amino acids from the C-terminal region of human Parp12|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 12; ARTD12; PARP-12; PARP12; poly (ADP-ribose) polymerase family, member 12; Poly [ADP-ribose] polymerase 12; poly ADP-ribose polymerase 12; ZC3HDC1; Zinc finger CCCH domain-containing protein 1; zinc finger CCCH type domain containing 1
Gene Aliases: 9930021O16; AA409132; AA536654; ARTD12; MST109; MSTP109; PARP-12; PARP12; ZC3H1; ZC3HDC1
Molecular Function: nucleic acid binding
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