|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:500|
|Western Blot (WB)||1:10-1:500|
|Immunohistochemistry (IHC)||See 2 publications below|
|Tested Species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminus of human Pax-5 protein|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-14585 targets Pax-5 in IHC (P) and Western blot applications and shows reactivity with Human and Mouse samples.
The MA5-14585 immunogen is synthetic peptide derived from the C-terminus of human Pax-5 protein.
PAX-5 is a B-cell-specific activator protein (BSAP). In the early stages of B cell developmemt, PAX-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. PAX-5 is expressed in most B-cell malignancies (pre-B and mature B cell lymphomas/leukemias). Over 90% of cases are positive for PAX-5 in Hodgkin's lymphoma, lymphoplasmacytic lymphoma, Merkel cell and small cell carcinoma. T-cell lymphomas, myeloma/plasmacytoma and carcinoid tumors are negative for PAX-5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B cell specific activator protein; B-cell lineage specific activator; B-cell-specific transcription factor; BSAP; paired box gene 5; paired box homeotic gene 5; Paired box protein Pax-5; paired domain gene 5; Pax5 variant 1; Pax5 variant 2; transcription factor PAX 5
Gene Aliases: ALL3; BSAP; EBB-1; KLP; Pax-5; PAX5
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.