|Immunocytochemistry (ICC)||Assay Dependent|
|Immunocytochemistry (ICC)||See 3 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Chemical|
|Published species reactivity||Zebrafish|
|Host / Isotype||Mouse / IgM|
|Storage buffer||PBS, pH 7.2, with 0.1% BSA|
|Contains||5mM sodium azide|
|Storage conditions||4° C|
Phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns(3, 4, 5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol (4, 5)-bisphosphate. PtdIns (3, 4, 5) P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring. The PH domain in a number of proteins binds to PtdIns (3, 4, 5) P3. Such proteins include Akt/PKB, PDK1, Btk1 and ARNO. The generation of PtdIns (3, 4, 5) P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity. The PH domain allows binding between PtdIns (3, 4, 5) P3 and G-protein coupled receptor kinases (GRKs). This enhances the binding of the GRK to the plasma membrane. [National Center for Biotechnology Information. PubChem Compound Database; CID=53477782]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C12H24O22P4; Phosphatidylinositol (3,4,5)-trisphosphate; Phosphatidylinositol 3,4,5-triphosphate; PIP3
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