|Western Blot (WB)||1:500-1:2000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human ATF1 around the phosphorylation site of Serine 63|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATF1; cAMP-dependent transcription factor ATF-1; cyclic AMP-dependent transcription factor ATF-1; Cyclic-AMP-dependent transcription factor ATF-1; TCR-ATF1; TREB36 protein
Gene Aliases: EWS-ATF1; FUS/ATF-1; TREB36
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