|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of tyrosine 402(V-N-Y(p)-E-E) derived from Human FER .|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
A suggested positive control for Western blot is JK or COS7 cells; suggested positive control for IHC is human brain tissue.
Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes. The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Feline encephalitis virus-related kinase FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p94-Fer; phosphoprotein NCP94; PPP1R74; protein phosphatase 1; protein phosphatase 1, regulatory subunit 74; Proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase Fer; regulatory subunit 74; TYK3; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Aliases: AV082135; C330004K01Rik; FER; Fert; Fert2; p94-Fer; PPP1R74; TYK3
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