|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of Serine 319/Serine 323 (D-S(p)-G-F-G-S(p)-T) derived from Human IL-10R subunit alpha.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
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Protein Aliases: CD210; CDw210a; I10R; I10R1; IL-10 receptor subunit alpha; IL-10R alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10RA; IL10R; IL10RA; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; Interleukin-10 receptor alpha chain precursor; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha
Gene Aliases: CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R; IL10RA
UniProt ID: (Human) Q13651
Entrez Gene ID: (Human) 3587
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