|Western Blot (WB)||1:500-1:2000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human IL-10R alpha around the phosphorylation site of Tyrosine 496|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: I10R; I10R1; IL-10 receptor subunit alpha; IL-10R alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10RA; IL10R; IL10RA; interleukin-10 receptor alpha chain; Interleukin-10 receptor alpha chain precursor; interleukin-10 receptor subunit 1; interleukin-10 receptor subunit alpha
Gene Aliases: CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
UniProt ID: (Human) Q13651
Entrez Gene ID: (Human) 3587
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