|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of Serine 83(R-V-S(p)-F-R) derived from Human MYT1.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
A suggested positive control for IHC is human breast carcinoma.
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.
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Protein Aliases: C20orf36; MTF1; Myelin transcription factor 1; Myelin transcription factor I; MyT1; MYTI; neural zinc finger transcription factor 2; PLPB1; proteolipid protein binding protein; Proteolipid protein-binding protein
Gene Aliases: C20orf36; KIAA0835; KIAA1050; MTF1; MYT1; MYTI; NZF2; PLPB1; ZC2H2C1; ZC2HC4A
UniProt ID: (Human) Q01538
Entrez Gene ID: (Human) 4661
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